thalidomide lietuviškai

Paaiškinimas anglų kalba

• a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis
• A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.